Jerantinine
Web28 giu 2024 · The development of an asymmetric and highly convergent three-component synthesis of the functionalized ABC ring system of the Aspidosperma alkaloid jerantinine E is reported. The presented synthetic strategy relies on our recently developed method for the one-pot β-C–H bromination of enones, which allows for rapid construction of the tricyclic … WebIndividual δ-tocotrienol and combined (δ-tocotrienol and jerantinine B) treatments induced G0/G1, whereas, IC 50 of jerantinine B induced G2/M cell cycle arrests in U87MG cells. This was mediated via the activation of Bid, Bax and cytochrome c activities. Interestingly, only the individual jerantinine B and combined treatments induced p53 ...
Jerantinine
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Web14 ott 2013 · Nature's beauty : The first total synthesis of the alkaloid natural product jerantinine E is based on a selective cyclization of an aminocyclopropane. Preliminary … Web28 gen 2016 · Jerantinine B (JB) is one of seven novel Aspidosperma indole alkaloids isolated from the leaf extract of Tabernaemontana corymbosa. Preliminary antiproliferative assays revealed that JB and JB acetate significantly inhibited growth and colony formation, accompanied by time- and dose-dependent apoptosis induction in human cancer cell lines.
WebInterestingly, only the individual jerantinine B and combined treatments induced p53 activation. These findings suggest that the combined treatment mediates an apoptosis … Web13 lug 2024 · The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad …
Web29 apr 2024 · PubMed Abstract: The jerantinine family of Aspidosperma indole alkaloids from Tabernaemontana corymbosa are potent microtubule-targeting agents with broad … Web26 mag 2016 · Conclusion: The present study demonstrated the mechanism for cytotoxic potency of δ-tocotrienol and jerantinine B against U87MG and HT-29 cells. …
Web26 mag 2016 · Aim of study. The present study was undertaken to study the mechanism of apoptosis induction in human glioblastoma (U87MG) and colorectal adenocarcinoma (HT-29) cancer cells by a novel indole alkaloid, jerantinine B isolated from T. corymbosa, δ-tocotrienol and the combined low-dose treatments of δ-tocotrienol with IC 20 dose of …
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